Cardiac inotropic and hypertrophic effects of Nigella sativa supplementation in rats

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Publication Details
Author list: El-Bahai MN, Al-Hariri MT, Yar T, Bamosa AO
Publisher: Elsevier
Publication year: 2009
Journal: International Journal of Cardiology
Volume number: 131
Issue number: 3
Start page: E115
End page: E117
Number of pages: 3
ISSN: 0167-5273
Web of Science ID: 000262328700044
PubMed ID: 17931720
Scopus ID: 58149180104

The intrinsic cardiac responses to 2-months Nigella sativa (black seed) oral supplementation (800 mg/kg) in rats were investigated. The isolated hearts were perfused in a Langendorff preparation to demonstrate the effects of N. sativa on the baseline inotropic and chronotropic functions and the myocardial flow rate. N. sativa supplementation induced moderate global (homogenous) cardiac hypertrophy, evident by significant increases in left ventricular and whole heart weights as well as the relative heart weight/body weight ratio. The isolated perfused hearts of Nigella-treated rats showed enhanced levels of baseline peak tension, maximum rate of tension development, heart rate and myocardial flow rate. Moreover, there was a significant increase in the tension developed per gram left ventricular weight. The present study provides the first evidence of a physiological cardiac hypertrophy in rats induced by long term N. sativa supplementation. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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Cardiac contractility, Cardiac hypertrophy, Inotropy, Intrinsic cardiac properties, Isolated hearts, Nigella sativa

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Last updated on 2018-18-09 at 11:18