Journal article
Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis


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Subtitle: Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis
Author list: Mohammed T. Al-Hariri,
Tharwat G. Eldin,
Tarek Hashim,
Shahanas Chathoth,
Abdullah Alswied

Publisher: Sultan Qaboos University
Publication year: 2019
Journal: Sultan Qaboos University Medical Journal
Journal acronym: SQUMJ
Volume number: 19
Issue number: 2
ISSN: 2075-051X
Web of Science ID:
PubMed ID:
Scopus ID:
eISSN: 2075-0528


abstract: Objectives: This study aimed to determine the effects of propolis on immune mediators and tissue
histopathology in rats with L-arginine-induced acute pancreatitis (AP). Methods: This study was conducted at
Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017. A
total of 24 male albino Wistar rats were divided into three equal groups. Group one was the negative control,
group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis). The rats in group three were treated with 100 mg/kg propolis for seven days after AP
induction. Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and
tumour necrosis factor-alpha (TNF-α) were measured. Results: Propolis reduced the quanitity of proinflammatory
molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall antiinflammatory effect of IL-22 (P <0.005) and reduced interstitial inflammation and neutrophil cell infiltration of
the pancreatic tissues. Conclusion: Propolis may exert a therapeutic effect in AP. Further studies are required to
demonstrate the mechanisms of propolis in AP.


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Last updated on 2019-11-09 at 14:06